Probiotics are considered the «snake oil» of the millennium, and doctors are reluctant to explore their full potential. However, preliminary data suggest that oral bacteriotherapy might be helpful in the management of COVID-19 infected patients.

The danger would be to either downplay the results on the general conviction that probiotics are not effective or to extrapolate these convincing results to other unstudied probiotics.

Let’s give due consideration to specific probiotic formulations that have shown proven efficacy in studies against COVID-19 such as Sivomixx®800.

(*) Two trials have been published, the first one showed that patients taking a specific product (Sivomixx®800) had an eight-fold reduced risk of being transferred to the ICU for mechanical ventilation.

The second one confirmed that the same probiotic formulation was associated with a significantly lower risk of fatal outcomes.

However, these results are specific for the formulation studied, and doctors must not extrapolate the results to other untested probiotic products.

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(1)  Cuozzo M. et al. Effects of Chronic Oral Probiotic Treatment in Paclitaxel-Induced Neuropathic Pain Biomedicines 2021 Mar 30;9(4):346.
doi: 10.3390/biomedicines9040346

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