The Blog of a Pioneer of the Intestinal Microbiota

Studies2018-01-08T14:10:25+00:00

Clinical studies and publications relating to the probiotic blend of Prof. Claudio De Simone

The probiotic blend invented by Prof. Claudio De Simone is the association of eight (8) strains of lactic acid bacteria and bifidobacteria which are part of the human microbiota or have been used in the food industry for decades. 31
It is currently available in North America under the trademark Visbiome® and in France and in Europe under the trademark Vivomixx®.

These notes refer to the article : «Confirmed interest of the probiotic blend 8 strains/450 billion bacteria for Ulcerative Colitis and its infectious complications»

1 Bibiloni, R., Fedorak, R.N., Tannock, G.W., Madsen, K.L., Gionchetti, P., Campieri, M., De Simone, C., and Sartor, R.B. (2005). The American journal of gastroenterology 100, 1539-1546.
2 Venturi, A., Gionchetti, P., Rizzello, F., Johansson, R., Zucconi, E., Brigidi, P., Matteuzzi, D., and Campieri, M. (1999). Alimentary pharmacology & therapeutics 13, 1103-1108.
3 Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K.M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., and Campieri, M. (2003). Gastroenterology 124, 1202-1209.
4 Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., and Campieri, M. (2000). Gastroenterology 119, 305-30.
5 Mimura, T., Rizzello, F., Helwig, U., Poggioli, G., Schreiber, S., Talbot, I.C., Nicholls, R.J., Gionchetti, P., Campieri, M., and Kamm, M.A. (2004). Gut 53, 108-114.
6 Kuhbacher, T., Ott, S.J., Helwig, U., Mimura, T., Rizzello, F., Kleessen, B., Gionchetti, P., Blaut, M., Campieri, M., Folsch, U.R., et al. (2006). Gut 55, 833-841.
7 Ulisse, S., Gionchetti, P., D’Alo, S., Russo, F.P., Pesce, I., Ricci, G., Rizzello, F., Helwig, U., Cifone, M.G., Campieri, M., et al. (2001). The American journal of gastroenterology 96, 2691-2699.
8 Miele, E., Pascarella, F., Giannetti, E., Quaglietta, L., Baldassano, R.N., and Staiano, A. (2009). The American journal of gastroenterology 104, 437-443.
9 Gionchetti, P., Rizzello, F., Morselli, C., Poggioli, G., Tambasco, R., Calabrese, C., Brigidi, P., Vitali, B., Straforini, G., and Campieri, M. (2007). Diseases of the colon and rectum 50, 2075-2082; discussion 2082-2074.
10 Gionchetti, P., Amadini, C., Rizzello, F., Venturi, A., and Campieri, M. (2002). Alimentary pharmacology & therapeutics 16 Suppl 4, 13-19.
11 Reid, G., and Hammond, J.A. (2005). Canadian family physician Medecin de famille canadien 51, 1487-1493.
12 Chapman, T.M., Plosker, G.L., and Figgitt, D.P. (2006). Drugs 66, 1371-1387.
13 Floch, M.H., Walker, W.A., Guandalini, S., Hibberd, P., Gorbach, S., Surawicz, C., Sanders, M.E., Garcia-Tsao, G., Quigley, E.M., Isolauri, E., et al. (2008). Journal of clinical gastroenterology 42 Suppl 2, S104-108.
14 Elahi, B., Nikfar, S., Derakhshani, S., Vafaie, M., and Abdollahi, M. (2008). Digestive diseases and sciences 53, 1278-1284.
15 Wong R., et al. Dig Dis Sci. 2015 Jan;60(1):186-94.
16 Guandalini S et al. J Pediatr Gastroenterol Nutr. 51:24-34 (2010).
17 Kim HJ. et al. Alim Pharmacol Ther 17:895-904 (2003).
18 Alisi, A., Bedogni, G., Baviera, G., Giorgio, V., Porro, E., Paris, C., Giammaria, P., Reali, L., Anania, F., and Nobili, V. (2014). Alimentary pharmacology & therapeutics 39, 1276-1285.
19 Mouli P. et al. Hepatol Res. 2015 Aug;45(8):880-9.
20 Dhiman R. et al. Gastroenterology 147:1327–1337 (2014).
21 Lunia K. et al. Clin Gastroenterol Hepatol. 2014 Jun;12(6):1003-8.
22 Agrawal A et al. Am J Gastroenterol 2012 Jul;107(7):1043-50.
23 Mittal VV et al. Eur J Gastroenterol Hepatol Aug;23(8):725–32 (2011).
24 Friederich, P., Verschuur, J., van Heumen, B.W., Roelofs, H.M., Berkhout, M., Nagtegaal, I.D., van Oijen, M.G., van Krieken, J.H., Peters, W.H., and Nagengast, F.M. (2011). International journal of colorectal disease 26, 575-582.
25 Turroni, S., Vitali, B., Candela, M., Gionchetti, P., Rizzello, F., Campieri, M., and Brigidi, P. (2010). World journal of gastroenterology : WJG 16, 30-41.
26 Pronio, A., Montesani, C., Butteroni, C., Vecchione, S., Mumolo, G., Vestri, A., Vitolo, D., and Boirivant, M. (2008). Inflammatory bowel diseases 14, 662-668.
27 Mariman, R., Kremer, B., Koning, F., and Nagelkerken, L. (2014). The British journal of nutrition 112, 1088-1097.
28 Mencarelli, A., Distrutti, E., Renga, B., D’Amore, C., Cipriani, S., Palladino, G., Donini, A., Ricci, P., and Fiorucci, S. (2011). PloS one 6, e22978.
29 Singh, S., Stroud, A.M., Holubar, S.D., Sandborn, W.J., and Pardi, D.S. (2015). The Cochrane database of systematic reviews 11, CD001176.
30 Guslandi, M. (2014). Current pharmaceutical design 20, 4561-4564.
31 Vivomixx contains : Streptococcus thermophilus DSM 24731, three bifidobacteria (B. breve DSM 24732, B. longumDSM 24736, B. infantis DSM 24737) and four lactobacilli (L. acidophilus DSM 24735, L. plantarum DSM 24730, L. paracasei DSM 24733, L. delbrueckii subsp. bulgaricus DSM 24734)