Alzheimer’s disease is a neurovegetative disorder that sees genetic predisposition and infectious processes among the leading etiological causes. Among the latter are gingivitis and periodontitis. A review by the Taiwanese group of Chun-Pin Chiang¹ wanted to deepen the issue and collected 26 articles on the main scientific search engines. This association was verified from the epidemiological point of view and post-mortem studies. The gene sequencing of the microbial of the oral cavity presented a constant predominance of Gram-negative bacteria as elements of inflammation of the oral cavity. This element, suggested the use of a specific strain of L. brevis for its anti-inflammatory capacities. A study on laboratory mice in which gingivitis was experimentally induced demonstrated a significant reduction of inflammation levels by the determination of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, and IL7A) by the action of the enzyme argininedeiminase present in the strain L. brevis itself. These findings have also been confirmed in human studies by Lee JK et al.³. Click here for more publications.