Rigorous clinical trial standards to test the Simone Formulation

In any clinical study, it is essential to avoid any bias that may distort the results. The clinical studies carried out on the De Simone Formulation have been the subject of the following study design:

• 43 randomized and/or controlled trials (double-blind, placebo-controlled, cross-over, with parallel arms)
• 7 uncontrolled open clinical trials
• 10 clinical proof-of-concept studies