Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

Probiotics represent a potential and interesting strategy to promote immune response against HPV and HPV-infected cells

A specific probiotic formulation might control anal HPV infection and HPV-related dysplasia in HIV-infected patients. Researchers at the University of Rome La Sapienza evaluated the potential clinical effects of oral bacteriotherapy on anal HPV infection (Human Papilloma Virus) related dysplasia in highly active anti-retroviral therapy (HAART) HIV-infected men having sex with men (MSM). The [...]

Add-on probiotic therapy reduces seizures for drug-resistant epilepsy patients

Reduction in seizures following add-on probiotic therapy in patients with drug-resistant epilepsy. Drug-resistant epilepsy (DRE) occurs in 25-30 per cent of patients with epilepsy (1), and current alternative therapies have shown limited effectiveness. The gut microbiota is known to regulate immunity and inflammation, metabolism, and neuronal signaling pathways (2), and alterations [...]

Relevance of De Simone Formulation in hepatic encephalopathy

De Simone Formulation combined with rifaximin positively affect the neurometabolic profile in a rat model of type C hepatic encephalopathy. Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by hepatic dysfunction secondary to chronic liver disease. Management of type C HE remains an important challenge because treatment options are [...]

Not all probiotics work in the same way in IBD

When a high-concentration probiotic (De Simone Formulation) was first included in the Gastroenterology Guidelines for the dietary management for IBD (Inflammatory Bowel Diseases) patients, it caused quite a stir. Analyzing this strategy in depth has allowed researchers to identify essential differences between the components included in the wide range of food supplements.A [...]

Probiotics as a new strategy for patients with Klebsiella pneumoniae rectal colonization

Infections caused by KPC-2 producing Klebsiella pneumoniae (KPCKP), are an increasing threat for hospitalized patients, because of the ability of carbapenemasi enzyme (KPC) to confer antibiotic-resistance. The Spanish group led by Ana del Rio published an observational study (1) on the efficacy of a 10-day non-absorbable oral antibiotic (NAA) regimen vs. the [...]

Highly concentrated probiotics for the intestinal health of patients with systemic sclerosis

Patients with Systemic Sclerosis (SSc) display important alterations in the gastrointestinal function, which are being studied by many researchers, such as the gastroenterologist Julian Thumboo and his colleagues from Singapore. The initial idea of Dr. Thumboo was to evaluate if a supplementation  with the De Simone Formulation could improve intestinal activity [...]

Highly concentrated probiotics to improve cognitive function

Recent evidences confirm that probiotics can modulate the intestinal microbiota, intestinal permeability and immune response: hence, the suggestive and reasonable hypothesis that an integration with probiotics could also improve the cognitive dysfunction and be helpful in patients affected by cirrhosis. This was the main goal of Dr Germán Soriano and colleagues, [...]

Autoimmune responses against intestinal bacteria are linked with type 1 diabetes

Microbiome sequence analyses have suggested that changes in gut bacterial composition are associated with autoimmune disease in humans and animal models. The mechanisms through which the gut microbiota influences autoimmune responses are still barely known. In a recent study, Jayne S. Danska and colleagues evaluated systemic antibody responses against cultured human [...]