Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

DSF and cirrhosis

DSF modulates serum metabolites in patients with cirrhosis Thirty-two patients with cirrhosis and cognitive dysfunction or a history of falls were enrolled in a recent study by Soriano, Laghi, and colleagues. The scope of the trial was to explore new approaches to improve cirrhotic patients' outcomes and health-related quality [...]

Chronic sleep restriction

Counteract the deleterious effects of sleep deprivation with SLAB51 to reduce stress and relieve anxiety and fatigue Sleep is a vital behavior that significantly impacts physical and mental well-being. Chronic sleep restriction (CRS), defined as inadequate sleep, is linked to an increased risk of chronic diseases and brain deficits, [...]

SLAB51 to spare oxygen during infections from respiratory syncytial virus, COVID-19 and influenza

SLAB51 to spare oxygen during infections from respiratory syncytial virus, COVID-19 and influenza By Professor Claudio De Simone  From Medical Xpress Newspaper headlines from the U.S. to the U.K. and most places in between highlight the surge in sick patients suffering from respiratory viruses. The so-called "tripledemic" of lung [...]

2023-01-17T09:06:10+01:00Covid, Slab51|

Study confirms Probiotic SLAB51 benefits COVID-19 hypoxic patients

Study confirms Probiotic SLAB51 benefits COVID-19 hypoxic patients Successful management of acute respiratory distress syndrome (ARDS) resulting from COVID-19 infection requires balancing adequate oxygenation and avoiding ventilator-induced lung injury (VILI). Recently reported data in Biomedicines (1) revealed that individuals with severe COVID-19 infections who required non-invasive oxygen therapy needed significantly less oxygen [...]

2022-12-08T16:55:07+01:00Covid, Slab51|

How probiotic Slab51 affects lipid metabolism in Alzheimer’s Disease

Preclinical and human studies have demonstrated the link between unbalanced gut microbiota and Alzheimer’s Disease (AD). However, there is still a lot of debate about how metabolic pathways are involved. Evidence indicates that neurodegenerative disorders are often associated with metabolic dysfunction, such as deregulation of lipid homeostasis, which may worsen neurological [...]

Probiotic Slab51 reduces chronic fatigue in patients following Covid hospitalization

Researchers reveal that long term effects of post-COVID fatigue are currently under reported and poorly understood against the wider backdrop of the global pandemic. Fatigue can linger for several months after Covid-19, leaving people feeling dull and finding it difficult to concentrate and recall memories. The results of a clinical study [...]

2022-03-21T09:32:22+01:00Covid, Slab51|

New insights confirm neuroprotective and anti-inflammatory effects of SLAB51

Gut dysbiosis is an established key player in the pathogenesis and/or development of age-related neurodegeneration, such as Alzheimer’s disease (AD). By altering the intestinal permeability and the blood-brain barrier, gut dysbiosis can promote neuroinflammation, oxidation, amyloid-beta deposition, insulin resistance, and neuronal degeneration. Oral bacteriotherapy represents a promising approach to strategically modulate [...]

2022-01-05T14:56:55+01:00Covid, Slab51|

Add-on probiotic therapy reduces seizures for drug-resistant epilepsy patients

Reduction in seizures following add-on probiotic therapy in patients with drug-resistant epilepsy. Drug-resistant epilepsy (DRE) occurs in 25-30 per cent of patients with epilepsy (1), and current alternative therapies have shown limited effectiveness. The gut microbiota is known to regulate immunity and inflammation, metabolism, and neuronal signaling pathways (2), and alterations [...]

The oxygen sparing effect of bacteriotherapy in COVID-19 (1)

The probiotic Slab51 (Sivomixx®800, Ormendes, Switzerland) has been evaluated in sixty-nine adult COVID-19 patients with a confirmed diagnosis of SARS-CoV-2 related pneumonia a CT lung involvement greater than 50 percent and requiring non-invasive oxygen therapy. Patients supplemented with Slab51 in addition to standard therapy (n=40) showed significantly higher blood levels of partial [...]

When an efficacious food supplement* suffers from being just a “probiotic”

Probiotics are considered the «snake oil» of the millennium, and doctors are reluctant to explore their full potential. However, preliminary data suggest that oral bacteriotherapy might be helpful in the management of COVID-19 infected patients. The danger would be to either downplay the results on the general conviction that probiotics are not [...]