Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

DSF and cirrhosis

DSF modulates serum metabolites in patients with cirrhosis Thirty-two patients with cirrhosis and cognitive dysfunction or a history of falls were enrolled in a recent study by Soriano, Laghi, and colleagues. The scope of the trial was to explore new approaches to improve cirrhotic patients' outcomes and health-related quality [...]

Chronic sleep restriction

Counteract the deleterious effects of sleep deprivation with SLAB51 to reduce stress and relieve anxiety and fatigue Sleep is a vital behavior that significantly impacts physical and mental well-being. Chronic sleep restriction (CRS), defined as inadequate sleep, is linked to an increased risk of chronic diseases and brain deficits, [...]

Further Evidence for the Role of Probiotics in Depression

Further Evidence for the Role of Probiotics in Depression Recent scientific research has been uncovering the intestinal microbiome's impact on the nervous system's development and functioning. The gut microbiome and specific neurobiological pathways are known as the "microbiome-gut-brain axis.” There are two main paths through which information can flow [...]

When an efficacious food supplement* suffers from being just a “probiotic”

Probiotics are considered the «snake oil» of the millennium, and doctors are reluctant to explore their full potential. However, preliminary data suggest that oral bacteriotherapy might be helpful in the management of COVID-19 infected patients. The danger would be to either downplay the results on the general conviction that probiotics are not [...]

Not all probiotics work in the same way in IBD

When a high-concentration probiotic (De Simone Formulation) was first included in the Gastroenterology Guidelines for the dietary management for IBD (Inflammatory Bowel Diseases) patients, it caused quite a stir. Analyzing this strategy in depth has allowed researchers to identify essential differences between the components included in the wide range of food supplements.A [...]

Probiotics as a new strategy for patients with Klebsiella pneumoniae rectal colonization

Infections caused by KPC-2 producing Klebsiella pneumoniae (KPCKP), are an increasing threat for hospitalized patients, because of the ability of carbapenemasi enzyme (KPC) to confer antibiotic-resistance. The Spanish group led by Ana del Rio published an observational study (1) on the efficacy of a 10-day non-absorbable oral antibiotic (NAA) regimen vs. the [...]

Probiotics during pregnancy, intestinal health and well-being

Pregnancy is a very particular moment in a woman's life during which many functional and metabolic parameters are carefully monitored. Among others, blood glucose, gestational weight gain (GWG), and the risk of gestational diabetes mellitus [GDM and glycated hemoglobin (HbA1c)] are constantly checked to avoid the risk of developing maternal pregnancy-related [...]