Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

A promising new therapeutic approach for major depressive disorder targets the microbiota-gut-brain axis: novel evidence

A promising new therapeutic approach for major depressive disorder targets the microbiota-gut-brain axis: novel evidence Major depressive disorder is one of the most common mental disorders and in some individuals it can result in severe impairments that interfere with or limit the ability to carry out major life activities. The concept [...]

The potential contribution of the gut-muscle axis to the pathophysiology of sarcopenia and reduced physical capacity in COPD patients

The potential contribution of the gut-muscle axis to the pathophysiology of sarcopenia and reduced physical capacity in COPD patients Chronic obstructive pulmonary disease (COPD) is an inflammatory condition of the respiratory system which can also affect multiple organs. Most patients with COPD develop muscle weakness and atrophy, which contribute to functional [...]

The promising role of DSF in fighting against autism

Autism spectrum disorders have an increasing prevalence characterized by enormous individual, family and social costs. There are growing interest and more resources addressed to researching the causes of this disease, which are still far from being fully and exhaustively defined. However, an interaction between genetic and environmental factors is implicated, converging [...]

Probiotics represent a potential and interesting strategy to promote immune response against HPV and HPV-infected cells

A specific probiotic formulation might control anal HPV infection and HPV-related dysplasia in HIV-infected patients. Researchers at the University of Rome La Sapienza evaluated the potential clinical effects of oral bacteriotherapy on anal HPV infection (Human Papilloma Virus) related dysplasia in highly active anti-retroviral therapy (HAART) HIV-infected men having sex with men (MSM). The [...]

Relevance of De Simone Formulation in hepatic encephalopathy

De Simone Formulation combined with rifaximin positively affect the neurometabolic profile in a rat model of type C hepatic encephalopathy. Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by hepatic dysfunction secondary to chronic liver disease. Management of type C HE remains an important challenge because treatment options are [...]

Not all probiotics work in the same way in IBD

When a high-concentration probiotic (De Simone Formulation) was first included in the Gastroenterology Guidelines for the dietary management for IBD (Inflammatory Bowel Diseases) patients, it caused quite a stir. Analyzing this strategy in depth has allowed researchers to identify essential differences between the components included in the wide range of food supplements.A [...]

Probiotics as a new strategy for patients with Klebsiella pneumoniae rectal colonization

Infections caused by KPC-2 producing Klebsiella pneumoniae (KPCKP), are an increasing threat for hospitalized patients, because of the ability of carbapenemasi enzyme (KPC) to confer antibiotic-resistance. The Spanish group led by Ana del Rio published an observational study (1) on the efficacy of a 10-day non-absorbable oral antibiotic (NAA) regimen vs. the [...]

Probiotics improve neurometabolic profile

Chronic liver disease is often caused by the hepatitis C virus and accompanied by neuropsychiatric complications called hepatic encephalopathy (HE). It can be a temporary or permanent condition and current treatments have some limitations in their efficacy and tolerability emphasizing the need for alternative therapies. There is increasing evidence that chronic liver [...]

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