Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

A promising new therapeutic approach for major depressive disorder targets the microbiota-gut-brain axis: novel evidence

A promising new therapeutic approach for major depressive disorder targets the microbiota-gut-brain axis: novel evidence Major depressive disorder is one of the most common mental disorders and in some individuals it can result in severe impairments that interfere with or limit the ability to carry out major life activities. The concept [...]

The potential contribution of the gut-muscle axis to the pathophysiology of sarcopenia and reduced physical capacity in COPD patients

The potential contribution of the gut-muscle axis to the pathophysiology of sarcopenia and reduced physical capacity in COPD patients Chronic obstructive pulmonary disease (COPD) is an inflammatory condition of the respiratory system which can also affect multiple organs. Most patients with COPD develop muscle weakness and atrophy, which contribute to functional [...]

The promising role of DSF in fighting against autism

Autism spectrum disorders have an increasing prevalence characterized by enormous individual, family and social costs. There are growing interest and more resources addressed to researching the causes of this disease, which are still far from being fully and exhaustively defined. However, an interaction between genetic and environmental factors is implicated, converging [...]

Add-on probiotic therapy reduces seizures for drug-resistant epilepsy patients

Reduction in seizures following add-on probiotic therapy in patients with drug-resistant epilepsy. Drug-resistant epilepsy (DRE) occurs in 25-30 per cent of patients with epilepsy (1), and current alternative therapies have shown limited effectiveness. The gut microbiota is known to regulate immunity and inflammation, metabolism, and neuronal signaling pathways (2), and alterations [...]

Relevance of De Simone Formulation in hepatic encephalopathy

De Simone Formulation combined with rifaximin positively affect the neurometabolic profile in a rat model of type C hepatic encephalopathy. Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by hepatic dysfunction secondary to chronic liver disease. Management of type C HE remains an important challenge because treatment options are [...]

The De Simone formulation has been tested in many therapeutic areas

Since 2000, the Simone Formulation has been studied in a wide range of therapeutic fields: 39 studies were carried out in the gastrointestinal area (Pouchitis, Ulcerative Colitis, Crohn's disease, IBD, diverticulitis, Microscopic colitis) 10 studies in liver diseases (Cirrhosis, Liver Failure, Hepatic Encephalopathy, Hepatic Steatosis) 11 studies in Bacterial Vaginosis, Sepsis, Dyspepsia, [...]

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