Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

Pr De Simone’s Blog, a Pioneer of the Gut Microbiota

About Pr. Claudio De Simone

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So far Pr. Claudio De Simone has created 388 blog entries.

Study confirms Probiotic SLAB51 benefits COVID-19 hypoxic patients

Study confirms Probiotic SLAB51 benefits COVID-19 hypoxic patients Successful management of acute respiratory distress syndrome (ARDS) resulting from COVID-19 infection requires balancing adequate oxygenation and avoiding ventilator-induced lung injury (VILI). Recently reported data in Biomedicines (1) revealed that individuals with severe COVID-19 infections who required non-invasive oxygen therapy needed significantly less oxygen [...]

2022-09-07T10:25:48+01:00Covid, Slab51|

A promising new therapeutic approach for major depressive disorder targets the microbiota-gut-brain axis: novel evidence

A promising new therapeutic approach for major depressive disorder targets the microbiota-gut-brain axis: novel evidence Major depressive disorder is one of the most common mental disorders and in some individuals it can result in severe impairments that interfere with or limit the ability to carry out major life activities. The concept [...]

The potential contribution of the gut-muscle axis to the pathophysiology of sarcopenia and reduced physical capacity in COPD patients

The potential contribution of the gut-muscle axis to the pathophysiology of sarcopenia and reduced physical capacity in COPD patients Chronic obstructive pulmonary disease (COPD) is an inflammatory condition of the respiratory system which can also affect multiple organs. Most patients with COPD develop muscle weakness and atrophy, which contribute to functional [...]

The promising role of DSF in fighting against autism

Autism spectrum disorders have an increasing prevalence characterized by enormous individual, family and social costs. There are growing interest and more resources addressed to researching the causes of this disease, which are still far from being fully and exhaustively defined. However, an interaction between genetic and environmental factors is implicated, converging [...]

How probiotic Slab51 affects lipid metabolism in Alzheimer’s Disease

Preclinical and human studies have demonstrated the link between unbalanced gut microbiota and Alzheimer’s Disease (AD). However, there is still a lot of debate about how metabolic pathways are involved. Evidence indicates that neurodegenerative disorders are often associated with metabolic dysfunction, such as deregulation of lipid homeostasis, which may worsen neurological [...]

2022-04-04T14:06:05+01:00Slab51|

Probiotic Slab51 reduces chronic fatigue in patients following Covid hospitalization

Researchers reveal that long term effects of post-COVID fatigue are currently under reported and poorly understood against the wider backdrop of the global pandemic. Fatigue can linger for several months after Covid-19, leaving people feeling dull and finding it difficult to concentrate and recall memories. The results of a clinical study [...]

2022-03-21T09:32:22+01:00Covid, Slab51|

New insights confirm neuroprotective and anti-inflammatory effects of SLAB51

Gut dysbiosis is an established key player in the pathogenesis and/or development of age-related neurodegeneration, such as Alzheimer’s disease (AD). By altering the intestinal permeability and the blood-brain barrier, gut dysbiosis can promote neuroinflammation, oxidation, amyloid-beta deposition, insulin resistance, and neuronal degeneration. Oral bacteriotherapy represents a promising approach to strategically modulate [...]

2022-01-05T14:56:55+01:00Covid, Slab51|

Probiotics represent a potential and interesting strategy to promote immune response against HPV and HPV-infected cells

A specific probiotic formulation might control anal HPV infection and HPV-related dysplasia in HIV-infected patients. Researchers at the University of Rome La Sapienza evaluated the potential clinical effects of oral bacteriotherapy on anal HPV infection (Human Papilloma Virus) related dysplasia in highly active anti-retroviral therapy (HAART) HIV-infected men having sex with men (MSM). The [...]

Add-on probiotic therapy reduces seizures for drug-resistant epilepsy patients

Reduction in seizures following add-on probiotic therapy in patients with drug-resistant epilepsy. Drug-resistant epilepsy (DRE) occurs in 25-30 per cent of patients with epilepsy (1), and current alternative therapies have shown limited effectiveness. The gut microbiota is known to regulate immunity and inflammation, metabolism, and neuronal signaling pathways (2), and alterations [...]

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