Le blog d'un pionnier du microbiote intestinal:/Pr. Claudio De Simone

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So far Pr. Claudio De Simone has created 264 blog entries.

Highly concentrated probiotics for the intestinal health of patients with systemic sclerosis

Patients with Systemic Sclerosis (SSc) display important alterations in the gastrointestinal function, which are being studied by many researchers, such as the gastroenterologist Julian Thumboo and his colleagues from Singapore. The initial idea of Dr. Thumboo was to evaluate if a supplementation  with the De Simone Formulation could improve intestinal activity [...]

Highly concentrated probiotics to improve cognitive function

Recent evidences confirm that probiotics can modulate the intestinal microbiota, intestinal permeability and immune response: hence, the suggestive and reasonable hypothesis that an integration with probiotics could also improve the cognitive dysfunction and be helpful in patients affected by cirrhosis. This was the main goal of Dr Germán Soriano and colleagues, [...]

Autoimmune responses against intestinal bacteria are linked with type 1 diabetes

Microbiome sequence analyses have suggested that changes in gut bacterial composition are associated with autoimmune disease in humans and animal models. The mechanisms through which the gut microbiota influences autoimmune responses are still barely known. In a recent study, Jayne S. Danska and colleagues evaluated systemic antibody responses against cultured human [...]

High concentration probiotics for healthier aging

The human gut microbiota is a huge ecosystem that provides numerous functions for host development, immune system, and metabolism. Thus, imbalance in the gut microbiota can be linked to many diseases, including human metabolic diseases such as obesity, type 2 diabetes, irritable bowel syndrome, and cardiovascular disease. Few studies, however, have focused [...]

The De Simone Formulation approved by the scientific community

On November 18, 2018, the Maryland Court of Justice condemned the pharmaceutical companies, VSL. Inc., Leadiant and Alfasigma, distributors of the probiotic VSL#3, to pay $15 million for false advertising and having deceived patients and doctors. As a result of this court decision, scientific authorities now recognize the De Simone Formulation [...]

Screening for rheumatoid arthritis passes through the microbiome of our mouth

The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis that the primary care provider must differentiate, in terms of diagnosis and treatment. Effective and non-invasive strategies for early detection [...]